Association between bisphosphonates and jaw osteonecrosis: a study in Wistar rats Maahs MP, Azambuja AA, Campos MM, Salum FG, Cherubini K. Association between bisphosphonates and jaw osteonecrosis: a study in Wistar rats. Head
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چکیده
Background: This work aimed at determining whether bisphosphonate therapy produces a sufficient condition for jaw osteonecrosis after tooth extraction. Methods: Rats were allocated into 3 groups: (1)11 rats treated with alendronate; (2)10 rats treated with zoledronic acid; (3)10 control rats. The animals were submitted to tooth extractions, and at the end of bisphosphonate therapy, they were euthanized. Histological sections of the surgical site were processed and analyzed. Results: The zoledronic acid group showed higher incidences of osteonecrosis, inflammatory infiltrate and microorganisms. There was no significant difference for epithelial or connective tissue, root fragments, vital bone and positive staining for vascular endotheial growth factor (VEGF) among the groups. Conclusions: Zoledronic acid is associated with jaw osteonecrosis, whereas alendronate did not produce a condition sufficient for osteonecrosis after tooth extraction. Neither zoledronic acid nor alendronate was associated with a reduced immunohistochemical expression of VEGF in vital bone at the tooth extraction site.
منابع مشابه
Microscopic Evaluation of the Effect of Oral Microbiota on the Development of Bisphosphonate-Related Osteonecrosis of the Jaws in Rats
OBJECTIVES Osteonecrosis of the jaws is a side effect associated with the use of bisphosphonates. Using histologic analysis, this study aimed to evaluate the influence of microbial colonies in the development of osteonecrosis in the jaws of rats subjected to nitrogenous and non-nitrogenous bisphosphonates, undergoing surgical procedures. MATERIAL AND METHODS Thirty-four rats (Rattus norvegicu...
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